The enzymes make a lot of sense in several circumstances:
 Disrupted DPP-IV:
 This is a "master" enzyme gene that controls what enzymes the body releases
 for digestion. It is damaged by organophosphate fertilizers and pesticides. If  you or your child has this damage (we do), Kirkman makes several  that contain this enzyme. Gluten persists and can be "read" in urine testing for 6-12
months after beginning the gluten-free regime.

Enzymes aren't something that "stays around" until needed. They are
activated by contact with whatever they are designed to digest.
Protease breaks down protein, cellulase breaks down fiber, sucrase
and galactase break down sugars, etc. So, each time they are used,
they break up whatever they come in contact with, are eliminated if
they don't contact anything, or are exhausted if the quantity of
whatever needs breaking down exceeds the available enzymes so
potentially not all the food is broken down for digestion if the
body's ability to do so is impaired.

This is why enzymes need to be given with food, and are not size-of-
the-person dependant, but size-of-the- meal dependant.

Naturally produced DPPIV also acts in an immune function protein. In
this capacity it is called CD26 (but its the same thing). As CD26, it
binds to and eliminates mercuric chloride & strep. The supplemental
sources (from plants) doesn't go after the toxins, just the
food...but if the body isn't using its own to break down food,
theoretically, there is more available for detox functions. Candida
converts marcury from an inorganic form to an organic form. If there
is food in the diet that helps keep a colony of Candida thriving, the
potential for environmental mercury exposure to continue being
incorporated. This is one loop that enzymes help to break.

So, what should you see in terms of effect? Used with each meal and
snack, it should break down food irritants and stop some of the
inflammation effect. Since that is subtle and primarily internal,
regular use can produce a happier child.

Regular use can take some load off the immune system, but you might
not see that in external behaviors.

It can shorten the time it takes to clear the system of residual
gluten, but again, this is something subtle and just clearing the
gluten brings the improved behavior.

For some, there is a big improvement in bowel function (our little
guy spontaneously potty trained age 3..YIPPEE!!) , and better quality
movements.

For others with growth problems, more nutrients are absorbed, so
there is improved growth and weight gain...again, not something you
would see immediately.

Our little guy was non-verbal, so I use everything we try on him. I
can report that we ran out of the DPPIV formula and substituted
another enzyme and had nausea and a "tight" twisted stomach feeling
without it that I never noticed before going on the diet and using
the enzymes.

We always use extra immediately following any accidental "forbidden"
food, followed by charcoal about 2 hrs later. Since our guy has gone
anaphylactic with an accidental peanut butter cheese cracker (a new
bus aide didn't know), it clearly has helped when there were
other "accidents".

So, initially, we gave/took enzymes with every meal and snack (2 for
adults, 1 for the kids). The diet (after 2 years) is completely clean
(the whole family) and now use it just for meals. The kids get it in
juice with the meals, those who can swallow the capsules, do.

---